Tatsuya Nakamura, Ph.D.
Assistant Professor
Department of Molecular Virology, Immunology and Medical Genetics
Biomedical Research Tower
460 W 12th Ave
Columbus, OH 43210
614/688-3215
tatsuya.nakamura@osumc.edu
Research Interests:
My research is focused on ALL1/MLL and its oncogenic derivative, ALL1 fusion protein generated in an aggressive form of acute leukemias. Since ALL1 is an epigenetic regulator with the histone methyltranserase activity, the main work in my lab has been directed toward understanding how the alteration of epigenetic marks leads to human cancer. Additional epigenetic regulators including ASH1, ALR (MLL2), CLLD8, JMJD1C and JMJD1A are also currently investigated.
Education & Training:
Jikei University Sch. of Med. M.D. 1976
Keio University Grad. Sch. of Medicine Ph.D. 1984
Recent Publications:
Garzon R, Volinia S, Liu CG, Fernandez-Cymering C, Palumbo T, Pichiorri F, Fabbri M, Coombes K, Alder H, Nakamura T, Flomenberg N, Marcucci G, Calin GA, Kornblau SM, Kantarjian H, Bloomfield CD, Andreeff M, Croce CM. (2008) MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia. Blood 111:3183-3189.
Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert T, Croce CM, Nakamura T, Canaani E, Young RA. (2008) Epigenetic Lesions at Genes Encoding Stem Cell Developmental Regulators in Human Mixed-lineage Leukemia. Genes and Development in press.
Pichiorri F, Okumura H, Nakamura T, Garrison P, Gasparini P, Suh S-S, Druck T, McCorkell KA, Barnes LD, Croce CM, Huebner K. (2008) Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions. J Biol Chem in press.
Di Leva G, Gasparini P , Piovan C , Iorio M , Garofalo M , Cristian T, Ngankeu A, Nakamura T, Alder H , Nuovo G, Liu Y, Volinia S, Nephew K, Croce CM. A regulatory "miRcircuitry" involving miR221&222 and ERa determines ERa status of breast cancer cells. Submitted.
