Guido Marcucci, MD
Assistant Professor
Department of Internal Medicine - Division of Hematology & Oncology
A437B Starling Loving Hall
320 West 10th Avenue
Columbus, OH 43210
Phone: (614) 293-5468
Fax: (614) 293-7527
guido.marcucci@osumc.edu

Research Interests
Molecular Biology and Cancer Genetics 
Experimental Therapeutics

Select Publications
Loss of C/EBP alpha and favorable prognosis of acute myeloid leukemias: a biological paradox. Perrotti D, Marcucci G, Caligiuri MA. J Clin Oncol 22(4): 582-284, 2004.

BAALC expression predicts clinical outcome of de novo acute myeloid leukemia patients with normal cytogenetics: a Cancer and Leukemia Group B study Whitman SP, Marcucci G, Caligiuri MA, de la Chapelle A, Bloomfield CD. Blood 102(5): 1613-1618, 2003. 

Characterization of leukemia-associated Rho guanine nucleotide exchange factor (LARG) expression during murine development Caligiuri MA, Marcucci G. Cell Tissue Res 314(3): 361-366, 2003.

Core binding factor (CBF) primary acute myeloid leukemia: Is the molecular monitoring by RT-PCR useful clinically Marcucci G, Bloomfield CD, Caligiuri MA. Eur J Haematol 71(3): 143-154, 2003.

Depsipeptide (FR 901228) promotes histone acetylation, gene transcription, apoptosis and its activity is enhanced by DNA methyltransferase inhibitors in AML1/ETO-positive leukemic cells Parthun MR, Whitman SP, Chan KK, Rush LJ, Plass C, Grever MR, Byrd JC, Marcucci G. Leukemia 17(2): 350-358, 2003.

Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase-8-mediated apoptosis and downregulation of c-FLIP protein Parthun MR, Marcucci G, Grever MR, Byrd JC. Blood 102(2): 652-658, 2003.

Depsipeptide (FR901228) inhibits proliferation and induces apoptosis in primary and metastatic human uveal melanoma cell lines Parthun MR, Marcucci G.

Invest Ophthalmol Vis Sci 44(6): 2390-2398, 2003.

Differential expression of histone post-translational modification in acute myeloid and chronic lymphocytic leukemia determined by high-pressure liquid chromatography and mass spectrometry Freitas MA, Parthun MR, Marcucci G, Byrd JC. J Am Soc Mass Spectrom 15(1): 77-86, 2003.

Identification of thiols and glutathione conjugates of depsipeptide FK228 (FR901228), a novel histone protein deacetylase inhibitor in the blood Byrd JC, Marcucci G, Grever MR, Chan KK. Rapid Commun Mass Spectrom 17(8): 757-766, 2003.