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Jeffrey D. Parvin, MD, PhD
Jeffrey D. Parvin, MD, PhD Professor and Interim-Chair Department of Biomedical Informatics 904 Biomedical Research Tower Tel: 614-292-0523 Email: Jeffrey.Parvin@osumc.edu
Research Interests: Systems Biology Methods for Discovery of Genes Involved in Breast Cancer 1. Nuclear function of the breast cancer specific tumor suppressor protein, BRCA1. 2. Centrosome function, breast cancer, and BRCA1. 3. Systems biology approaches for the discovery of genes important in breast cancer. 4. Identification of ubiquitin conjugates after DNA damage.
Recent publications: Horwitz AA, Affar EB, Heine GF, Shi Y, and Parvin JD. A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase. Proc Natl Acad Sci USA 2007 104, 6614-9. Pujana, MA*, Han, JD*, Starita, LM*, Stevens, Kn*, Tewari, M, Ahn, JS, Rennert, G, Moreno, V, Assmann, V, ElShamy, WM, J Rual, JF, Rozek, LS, Gelman, RS, Gunsalus, KC, Greenberg, RA, Sobhian, B, Bertin, N, Venkatesan, K, Ayivi-Guedehoussou, N, Lázaro, C, Nathanson, KL, Weber, BL, Cusick, ME, Hill, DE, Livingston, DM, Gruber, SB**, Parvin, JD**, and Vidal, M**. Network modeling links breast cancer susceptibility and centrosome dysfunction. Nat Genet 2007 39, 1338-49. (*co-first authors; **co-corresponding authors) Sankaran S, Crone DE, Palazzo RE, and Parvin JD. Aurora A Kinase Regulates BRCA1 Inhibition of Centrosome-Dependent Microtubule Nucleation. Cancer Res 2007 67, 11186-94. Sankaran S, Crone DE, Palazzo RE, and Parvin JD. BRCA1 regulates ?-tubulin binding to centrosomes. Cancer Biology and Therapy 2007 6, 1853-7. Heine, GF, Horwitz AA, and Parvin JD. Multiple mechanisms contribute to inhibit transcription in response to DNA damage. J Biol Chem 2008 283, 9555-61.
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